Domino's Pizza

Looking for great pizza in Port St Lucie? Domino's is your go-to destination for delicious pizza and a wide range of mouthwatering menu options. Whether you're craving classic pepperoni pizza, cheesy pasta, stuffed cheesy bread, flavorful salads, or chicken wings, our Port St Lucie pizza location has got you covered. Enjoy the convenience of delivery, carryout, or curbside pickup with our exclusive Domino's Carside Delivery service. Wherever you are, we have an option for pizza near you. Explore our menu, discover local coupons, and track the status of your lunch, dinner, or late-night order at 10642 S Federal Hwy.