Luisa's Restaurant Wine Bar Since 1959 is a locally owned and operated Italian restaurant located in the heart of San Francisco, CA, offering a wide variety of delicious dishes to suit every taste. Our menu features classic Italian food, such as pizza, pasta, seafood, antipasti, and homemade pasta, all made with the freshest ingredients and prepared with care by our talented team of chefs. At Luisa's Restaurant Wine Bar Since 1959, we believe that dining out should be an experience, which is why we also offer a wide selection of wine and create a warm and inviting atmosphere for you to enjoy.